EVALUATION OF BIOACTIVE POTENTIAL OF DALBERGIA SISSOO (ROXB.) AND CARALLUMA TUBERCULATA (N.E.BR.) AND THEIR TOXICOLOGICAL ASSESSMENT.
Main Article Content
Keywords
Pharmacological, safety, Antioxidant, Antidiabetic, Herbal, Insecticidal, Phytotoxic, Anticancer, Diabetes mellitus, Dalbergia sissoo, Caralluma tuberculata, medicinal plants
Abstract
Dalbergia sisso (Roxb.) and Caralluma tuberculata (N.E.Br.) are extremely useful medicinal plant species distributed in various parts of the world including Pakistan. Traditionally Pakistani people use these plants to treat Diabetes mellitus, arthritis, obesity, and certain cardiovascular problems. Folks are using these medicinal plants abundantly. There is a dire need to perform scientific screening of these valuable plants. In order to establish evidence based resource regarding the ethno botanical use of these herbs present studies were carried out. The diverse phytopharmacological activities comprising of in-vitro antidiabetic, antioxidant, anticancer, phytotoxic, insecticidal and brine shrimp activities were carried out. Promising antioxidant and in vitro antidiabetic actions were explored. Both species were found safe and effective with considerable anti- oxidant and antidiabetic actions. Further in depth in vivo research is required to validate the safe and effective use of these valuable traditional herbal therapeutic alternatives.
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2. Ahn, K. (2017). The worldwide trend of using botanical drugs and strategies for developing global drugs. BMB reports, 50(3), 111.
3. Akram, H., Ullah, I., Nabi, H., Shahzad, N., Ahmad, M., & Farzand, A. (2023). Optimization of plant spacing for yield improvement in hybrid maize using DSSAT. Agrobiological Records 14: 37-49.
4. Ali, K., Ghous, H. F., Shehzadi, N., Haroon, O., Rashid, S., & Rahimi, M. (2023). Exploring the potential of next generation sequencing in plant breeding and genetics.
5. Bennett, P. N., & Brown, M. J. (2007). Clinical Pharmacology E-Book: With STUDENTCONSULT Access: Elsevier health sciences.
6. Brenzan, M. A., Nakamura, C. V., Prado Dias Filho, B., Ueda-Nakamura, T., Young, M. C. M., & Aparício Garcia Cortez, D. (2007). Antileishmanial activity of crude extract and coumarin from Calophyllum brasiliense leaves against Leishmania amazonensis. Parasitology research, 101, 715-722.
7. Cao, B., Wei, X.-C., Xu, X.-R., Zhang, H.-Z., Luo, C.-H., Feng, B., . . . Han, L. (2019). Seeing the unseen of the combination of two natural resins, frankincense and myrrh: Changes in chemical constituents and pharmacological activities. Molecules, 24(17), 3076.
8. Degla, L. H., Kuiseu, J., Olounlade, P. A., Attindehou, S., Hounzangbe-Adote, M., Edorh, P. A., & Lagnika, L. (2022). Use of medicinal plants as alternative for the control of intestinal parasitosis: Assessment and perspectives. Agrobiol Rec, 7, 1-9.
9. Garg, S., Kaul, S. C., & Wadhwa, R. (2018). Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms. International journal of oncology, 52(1), 19-37.
10. Gupta, S. (1994). Prospects and perspectives of natural plants products in medicine. Indian Journal of pharmacology, 26(1), 1-12.
11. Haroon, M., Anas, M., Naurin, I., Afzal, R., Irfan, U., Tariq, H., . . . Rukh, M. (2023). Autoimmunity in plants; a powerful weapon in Kingdom Plantae to combat stresses.
12. Hatami, S., Hatami Badrbani, M., & Kahrizi, D. (2024). Data Mining Approach in the Agricultural Industry, Medicinal Plants (case study); A Review. Journal of Medicinal plants and By-Products, 13(2), 247-256.
13. Hirono, I., & Grasso, P. (1981). Natural carcinogenic products of plant origin. CRC critical reviews in Toxicology, 8(3), 235-277.
14. Islam, R., Rahman, M. S., & Rahman, S. M. (2015). GC-MS analysis and antibacterial activity of Cuscuta reflexa against bacterial pathogens. Asian Pacific Journal of Tropical Disease, 5(5), 399-403.
15. Khera, N., & Bhatia, A. (2014). MEDICINAL PLANTS AS NATURAL ANTI-DIABETIC AGENTS. International Journal of Pharmacy & Life Sciences, 5(3).
16. Kumari, A., & Kakkar, P. (2008). Screening of antioxidant potential of selected barks of Indian medicinal plants by multiple in vitro assays. Biomedical and environmental sciences, 21(1), 24-29.
17. Laakso, M. (1999). Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes, 48(5), 937-942.
18. Lee, C., Yim, M. B., Chock, P. B., Yim, H.-S., & Kang, S.-O. (1998). Oxidation-reduction properties of methylglyoxal-modified protein in relation to free radical generation. Journal of biological chemistry, 273(39), 25272-25278.
19. Meshram, P. (2000). Antifeedant and insecticidal activity of some medicinal plant extracts against Dalbergia sissoo defoliator Plecoptera reflexa Gue.(Lepidoptera: Noctuidae).
20. Mubashir, A., Ghani, A., & Mubashar, A. (2022). Common medicinal plants effective in peptic ulcer treatment: a nutritional review.
21. Rahbar, S., & Figarola, J. L. (2003). Novel inhibitors of advanced glycation endproducts. Archives of biochemistry and biophysics, 419(1), 63-79.
22. Rehman, I., Shaukat, F., Anwar, Z., Ijaz, A., & Nadeem, R. (2022). Applications of Crispr/Cas system in plants.
23. Sarah, Q. S., Anny, F. C., & Misbahuddin, M. (2017). Brine shrimp lethality assay. ||| Bangladesh Journal of Pharmacology, 12(2), 186-189.
24. Wang, W., & Williams, J. M. (1990). The use of phytotoxicity tests (common duckweed, cabbage, and millet) for determining effluent toxicity. Environmental monitoring and assessment, 14, 45-58.
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Aug 24, 2024
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How to Cite
Ijaz Ali, Javeria Arshad, Umar Farooq, Irfana Lalarukh, Mahrukh, Sohaib Iqbal, Muhammad Abdul Haq Khan, Muhammad Muzammil Ramzan, Sajid Ahmad, Nayab Zehra, & Fasih Ur Rehman. (2024). EVALUATION OF BIOACTIVE POTENTIAL OF DALBERGIA SISSOO (ROXB.) AND CARALLUMA TUBERCULATA (N.E.BR.) AND THEIR TOXICOLOGICAL ASSESSMENT. Journal of Population Therapeutics and Clinical Pharmacology, 31(8), 1969-1972. https://doi.org/10.53555/a03rmb08
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Author Biographies
Ijaz Ali
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University Faisalabad-PakistanJaveria Arshad
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Punjab - PakistanUmar Farooq
Department of Pharmacy, COMSATS University Abbottabad-Pakistan.Irfana Lalarukh
Department of Botany, Government College Women University Faisalabad-Pakistan.Mahrukh
Department of Botany, Government College Women University Faisalabad-Pakistan.Sohaib Iqbal
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Punjab - PakistanMuhammad Abdul Haq Khan
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University Faisalabad-PakistanMuhammad Muzammil Ramzan
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University Faisalabad-PakistanSajid Ahmad
Department of Pharmacy Government College University Faisalabad-Pakistan.Nayab Zehra
Department of Botany, Government College Women University Faisalabad-Pakistan.Fasih Ur Rehman
Department of Pharmacy Government College University Faisalabad-Pakistan.How to Cite
Ijaz Ali, Javeria Arshad, Umar Farooq, Irfana Lalarukh, Mahrukh, Sohaib Iqbal, Muhammad Abdul Haq Khan, Muhammad Muzammil Ramzan, Sajid Ahmad, Nayab Zehra, & Fasih Ur Rehman. (2024). EVALUATION OF BIOACTIVE POTENTIAL OF DALBERGIA SISSOO (ROXB.) AND CARALLUMA TUBERCULATA (N.E.BR.) AND THEIR TOXICOLOGICAL ASSESSMENT. Journal of Population Therapeutics and Clinical Pharmacology, 31(8), 1969-1972. https://doi.org/10.53555/a03rmb08