A STUDY OF TREATMENT OUTCOMES AND GENDER BASED DIFFERENCES OF SYMPTOMS TUBERCULOSIS PATIENTS WITH DIABETES MELLITUS: A COHORT STUDY

Main Article Content

Kamran Ali Qureshi
Saleem Shahzad
Mehwish Abrar
Muhammad Rashid Qureshi
Naeema Asghar
Muhammad Muddasser Khan Panezai

Keywords

Tuberculosis Treatment Outcome, Health Status, Diabetes Mellitus

Abstract

OBJECTIVE: This study was conducted to evaluate the gender-based differences of symptoms among TB patients having Diabetes mellitus.


BACKGROUND: In developing nations, the rise in type 2 diabetes worldwide is acknowledged as a threat to the prevention of TB. Worldwide, there are 9.6 million new cases of active tuberculosis reported year, of which one million additionally have diabetes.


STUDY DESIGN: A cohort study


PLACE AND DURATION: This study was conducted in Liaquat University of Medical & Health Sciences Jamshoro from January 2023 to January 2024


METHODOLOGY: This study was conducted among newly registered pulmonary TB (PTB) with DM cases. All the patients with tuberculosis were initially included in the study.  In the initial interview, 76 patients participated, 03 patient was lost to follow-up. Thus, at the conclusion of the intense period, a first follow-up visit was conducted with 73. The data was entered and analyzed using SPSS version 26.0


RESULTS: There were 51 (69.86%) males and 22 (30.13%) females in the study. The highest proportion (35.62%) belonged to age group 51 to 60 years. Cough was the most common (97.26%) among patients. Loss of weight was observed in 89.04%, weakness, anorexia, mild fever and hemoptysis was observed in 84.93%, 75.34%, 69.86%, and 27.4% respectively.


CONCLUSION: The individuals with TB and DM are more likely to be female, older, obese, and less educated. In the current investigation, the majority of patients were male, literate, between the ages of 51 and 60, living in an urban residential area and belonging to the middle socioeconomic level.

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References

1. Restrepo BI. Diabetes and tuberculosis. Microbiol Spectr 2016;4:10.1128/microbiolspec.TNMI7‑0023‑2016.
2. Zheng C, Hu M, Gao F. Diabetes and pulmonary tuberculosis: A global overview with special focus on the situation in Asian countries with high TB‑DM burden. Glob Health Action 2017;10:1264702.
3. Araia ZZ, Mesfin AB, Tewelde AG, Osman R, Tuumzghi HA. Diabetes mellitus and its associated factors in tuberculosis patients in Maekel Region, Eritrea: Analytical cross‑sectional study. Diabetes Metab Syndr Obes 2021;14:515‑23.
4. Baghaei P, Marjani M, Javanmard P, Tabarsi P, Masjedi MR. Diabetes mellitus and tuberculosis facts and controversies. J Diabetes Metab Disord 2013;12:58.
5. Yorke E, Atiase Y, Akpalu J, Sarfo‑Kantanka O, Boima V, Dey ID. The Bidirectional relationship between tuberculosis and diabetes. Tuberc Res Treat 2017;
6. Lin Y, Harries AD, Kumar AM, Critchley JA, Crevel RV, Owiti P, et al. Management of Diabetes Mellitus Tuberculosis: A Guide to the Essential Practice. 1st ed. Paris, Available from: theunion. org/sites/ default/files/2020‑11/TheUnion_DMTB_Guide.pdf.
7. National Health Mission. National framework for joint TB Diabetes collaborative activities 2017. https://tbcindia.gov.in/WriteReadData/National%20framework%20for%20joint%20TB%20 diabetes%2023%20Aug%202017.pdf
8. World Health Organization. Tuberculosis and Diabetes facts 2016. Available from: https://www.who.int/news/item/07‑05‑2016‑world health‑day‑joining‑forces‑to‑fight‑tb‑and‑diabetes#:~:text=Ending%20 TB%20by%202030%20is,Prevention%20and%20Control%20of%20 NCDs. [Last accessed on 2022 Oct 28].
9. Reis‑Santos B, Locatelli R, Horta BL, Faerstein E, Sanchez MN, Riley LW, et al. Socio‑demographic and clinical differences in subjects with tuberculosis with and without diabetes mellitus in Brazil – A multivariate analysis. PLoS One 2013;8:e62604.
10. Tahir Z, Ahmad MD, Akhtar AM, Yaqub T, Mushtaq MH, Javed H. Diabetes mellitus among tuberculosis patients: A cross sectional study from Pakistan. Afr Health Sci 2016;16:671‑6.
11. Alisjahbana B, Sahiratmadja E, Nelwan EJ, Purwa AM, Ahmad Y, Ottenhoff THM, et al. The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis. Clin Infect Dis 2007;45:428–35.
12. Chiang CY, Bai KJ, Lin HH, Chien ST, Lee JJ, Enarson DA, et al.the influence of diabetes, glycemic control, and diabetes‑relatedcomorbidities on pulmonary tuberculosis. PLoS One 2015;10:e0121698.
13. Juliasih NN, Mertaniasih NM, Hadi C, Soedarsono S, Sari RM, Alfian IN. Factors affecting tuberculosis patients’ quality of life in Surabaya, Indonesia. J Multidiscip Healthc 2020;13:1475–80.
14. Shariefuddin WWA, Sari SYI, Pandji TD. Comparison of life quality between diabetic and diabetic with tuberculosis patients. Althea Med J 2016;3:440–5.
15. Pande T, Huddart S, Xavier W, Kulavalli S, Chen T, Pai M, et al. Prevalence of diabetes mellitus amongst hospitalized tuberculosis patients at an Indian tertiary care center: A descriptive analysis. PLoS One 2018;13:e0200838.
16. Workneh MH, Bjune GA, Yimer SA. Diabetes mellitus is associated with increased mortality during tuberculosis treatment: A prospective cohort study among tuberculosis patients in South‑Eastern Amahra Region, Ethiopia. Infect Dis Poverty 2016;5:22.
17. Carreira S, Costeira J, Gomes C, André JM, Diogo N. Impact of diabetes on the presenting features of tuberculosis in hospitalized patients. Rev Port Pneumol 2012;18:239‑43.