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Dr. Iqra Azeem
Dr Jhanvi Jasrotia
Dr. Arti Sakral


Pemhigus, Desmoglein 3, Mycophenolate mofetil, Occular involvement, Sepsis


Pemphigus is a life-threatening mucocutaneous immunobullous disorder affecting the skin and mucous membrane which is clinically presented by vesicle formation and histologically by intraepithelial cleft and acantholysis. Pemphigus vulgaris is a common autoimmune blistering disease always affecting the oral mucosa and it can be the initial site of presentation before involving the skin or other mucous membranes. The oral manifestations of pemphigus vulgaris typically run a chronic course causing blisters, erosions and ulcers of the oral mucosa. The dermal manifestation is not a common occurrence and many times the oral lesions are the primary clinical presentation of pemphigus vulgaris.

In this case report, we present the case of a 76-year-old woman who was admitted to our hospital with extensive pemphigus vulgaris. The patient presented with a complex and severe form of the disease, characterised by widespread blisters and lesions on her back, chest, pelvis, left eye, and abdomen, leading to septic shock. The case highlights the challenges faced by patients with this condition in rural areas of India, where access to specialised healthcare services may be limited.

The patient's treatment plan was managed by a team of healthcare professionals from various disciplines, who worked together to provide comprehensive care. This case report aims to highlight the importance of aggressive treatment and multidisciplinary care in managing patients with pemphigus vulgaris in rural areas of India.

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