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Farzana Iftikhar
Shazia Perveen
Sumaira Kanwal
Iram Qadeer
Muhammad Mazhar Ayaz
Khawar Ali Shahzad


Solanum nigrum, Rotenone, Histopathology, fruit extract. Tissue damage, Tissue damage, Therapeutic effect


Solanum nigrum is used as a traditional medicinal plant to treat pneumonia. It has a widespread antioxidant, antimalarial, antimicrobial, wound healing, and anti-inflammatory activities. These activities are due to the presence of alkaloids, steroids, triterpenes, tannins, flavonoids, flavones, phenols, and glycosides. Parkinson disease (PD) is a most chronic and most progressive disease of the central nervous system. On a daily basis more than 100 people are diagnosed with Parkinson’s disease. To study the effect of Solanum nigrum polyphenolic compounds on Parkinson’s disease rotenone induced Parkinson’s model was prepared. Solanum nigrum fruit extract contents were identified by Gas chromatograph mass spectrometry (GCMS) analysis. Rats were divided into four groups. First group as control group given sun flower oil, second group was given rotenone third group was given rotenone + Solanum nigrum fruit extract and the fourth group was treated with Solanum nigrum fruit extract. The second group showed Parkinson disease which was confirmed by different behavioral and chemical tests The third and fourth group showed therapeutic effect as compared to rotenone treated group. At necropsy, organ weight measurement and macroscopic evaluations of the kidney, liver, lungs and heart. Data analysis indicated that rotenone treated rats’ damages body vital organs liver, kidney, heart and lungs tissues badly. The Solanum nigrum treated group histopathology showed that polyphenolic compounds have therapeutic effect on of kidney, liver and heart and not significant therapeutic effect on lungs.

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