DESIGN, SYNTHESIS, AND BIO-EVALUATION OF NEW 2-[(5-SUBSTITUTED ARYL-3-MERCAPTO-1H-1, 2,4-TRIAZOL-1-YL) METHYL]-1H-ISOINDOLE-1,3(2H)-DIONE DERIVATIVES
Main Article Content
Keywords
isoindoline-1, 3-dione, in vivo anti-bacterial activity
Abstract
A new isoindoline-1,3-dione derivatives were synthesized and evaluated for their anti-bacterial activity. The target compounds 2-[(5-substitutedaryl-3-mercapto-1H-1,2,4-triazol-1-yl) methyl]-1H-isoindole-1,3(2H)-dione derivatives were obtained by condensation of N-hydroxymethylphthalimide and thiocarbohydrazide to form 2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) methyl] hydrazine-1-carbothioamide and reacted with different aromatic acids. The structures of the synthesized derivatives were confirmed using IR and 1H-NMR spectral data. The antibacterial activity was determined by Mueller–Hinton well diffusion method. The results revealed the importance of the combination of 1,2,4 triazole and phthalimide moieties as a promising antibacterial agent.
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Valarmathy Joshua
Department of Pharmaceutical Chemistry, PPG College of Pharmacy, Saravanampatti, Sathyamangalam Main road, Coimbatore - 641035, Tamilnadu, India.
L. Samuel Joshua
Department of Pharmaceutical Chemistry, Padmavathi college of Pharmacy and Research Institute, Krishnagiri main road, Periyanahalli, Dharmapuri-635205, Tamilnadu, India.
Sherlyn Joshua
UV Gullas College of Medicine, 6014 Mandaue City, Cebu, Philippines.
Vinolyn Joshua
UV Gullas College of Medicine, 6014 Mandaue City, Cebu, Philippines.
W.D. Sam Solomon
Department of Pharmaceutical Chemistry, PPG College of Pharmacy, Saravanampatti, Sathyamangalam Main road, Coimbatore - 641035, Tamilnadu, India.