ESTIMATE OF ETHANOLIC EXTRACT OF YOUNG SHOOTS OF BAMBUSA ARUNDINACEA FOR ANTIOXIDANT & ANTIDIABETIC ACTIVITIES
Main Article Content
Keywords
.
Abstract
The Indian tribes of northwestern India have long employed the Poaceae plant Bambusa arundinacea to treat diabetes. Antioxidant substances contribute to good health by countering reactive oxygen species (ROS), which are involved in a variety of disease processes such as insulin resistance, atherosclerosis, cardiovascular disease and coronary heart disease. Diabetes Mellitus is biggest problem in now days in World and a big challenge for researcher and scientist, to overcome this problem by various medicines but not achieve good performance regarding treatment of diabetes. Researcher main focus on phytochemicals used in the treatment of diabetes with less adverse effect. The goal of the current study was to assess the young shoot of Bambusa arundinacea's toxicity, antioxidant activity (In vivo) and antidiabetic activity (In vivo) in rats that had been given alloxan-induced diabetes. Rats given BAEE treatment demonstrated antioxidant (In vivo) qualities according to SGOT, SGPT, and ALP assessments. BAEE demonstrated the presence of b sitosterol and gallic acid. In alloxan-induced diabetic rats, administration of BAEE at 200 and 500 mg/kg resulted in a significant decrease in fasting blood glucose, whereas plasma insulin levels were raised in comparison to diabetic control. Comparing both doses to glibenclamide-diabetic rats revealed that they were equally effective. This study suggests that BAEE have both in vivo antidiabetic and in vivo antioxidant properties. The presence of putative antioxidants may be the cause of the overall action.
Conclusion- Ethanolic extract of young shoots of Bambusa arundinacea shows dose dependent therapeutic efficacy for anti oxidant and anti diabetic activity. Efficacy increases with increasing the dose.
Conclusion- Ethanolic extract of young shoots of Bambusa arundinacea shows dose dependent therapeutic efficacy for anti oxidant and anti diabetic activity. Efficacy increases with increasing the dose.
References
1. Krishnaiah D, Sarbatly R, Nithyanandam RJ. A review of the antioxidant potential of medicinal plant species. Food and bioproducts processing. 2011;89(3):217-33.
2. Shahidi FJ. Nutraceuticals, functional foods and dietary supplements in health and disease. Journal of food and drug analysis. 2012;20(1):78.
3. El-Kaissi S, Sherbeeni SJ. Pharmacological management of type 2 diabetes mellitus: an update. Current diabetes reviews. 2011;7(6):392-405.
4. Hasbal G, Yilmaz-Ozden T, Can AJ. Antioxidant and antiacetylcholinesterase activities of Sorbus torminalis (L.) Crantz (wild service tree) fruits. Journal of food and drug analysis. 2015;23(1):57-62.
5. Asano NJ. Sugar-mimicking glycosidase inhibitors: bioactivity and application. Cellular and Molecular Life Sciences. 2009;66:1479-92.
6. Standl E, Schnell OJ. Alpha-glucosidase inhibitors 2012–cardiovascular considerations and trial evaluation. Diabetes and Vascular Disease Research. 2012;9(3):163-9.
7. Jung M, Park M, Lee HC, Kang Y-H, Kang ES, Kim SKJ. Antidiabetic agents from medicinal plants. Current medicinal chemistry. 2006;13(10):1203-18.
8. Jin H, Zhang Y-J, Jiang J-X, Zhu L-Y, Chen P, Li J, et al. Studies on the extraction of pumpkin components and their biological effects on blood glucose of diabetic mice. Journal of food and drug analysis. 2013;21(2):184-9.
9. Misbah H, Aziz AA, Aminudin NJ. Antidiabetic and antioxidant properties of Ficus deltoidea fruit extracts and fractions. BMC complementary and alternative medicine. 2013;13:1-12.
10. Niedowicz DM, Daleke DLJ. The role of oxidative stress in diabetic complications. Cell biochemistry and biophysics. 2005;43:289-330.
11. Spadiene A, Savickiene N, Ivanauskas L, Jakstas V, Skesters A, Silova A, et al. Antioxidant effects of Camellia sinensis L. extract in patients with type 2 diabetes. journal of food and drug analysis. 2014;22(4):505-11.
12. Niedowicz DM, Daleke DLJCb, biophysics. The role of oxidative stress in diabetic complications. Cell biochemistry and biophysics. 2005;43:289-330.
12. Parihar, S., Sharma, D. 2021. Cynodondactylon: A Review of Pharmacological Activities. Sch Acad J Pharm 11, 183-189.
13. Parihar, S., Sharma, D. 2021. Navagraha (nine planets) plants: the traditional uses and the therapeutic potential of nine sacred plants of india that symbolises nine planets. IJRAR 8 (4), 96-108.
14. Germano M, d’Angelo V, Biasini T, Sanogo R, De Pasquale R, Catania SJJoe. Evaluation of the antioxidant properties and bioavailability of free and bound phenolic acids from Trichilia emetica Vahl. 2006;105(3):368-73.
15. Chanda S, Dudhatra S, Kaneria MJF, function. Antioxidative and antibacterial effects of young shoots and fruit rind of nutraceutical plants belonging to the Fabaceae family. 2010;1(3):308-15.
16. Chopra RJCsidoIn, Calcutta. UN Dhar, Ltd SP. I. C. Chopra, KL Handa and LD Kapur. 1958.525.
17. Foster D, Cornella TJVA, D. VanNostrand Company Inc. Princeton, New Jersey, New York. Colorimetric Method of Analysis, Vol. 1961;162.
18. Bhaduri B, Ghose CR, Bose AN, Moza BK, Basu UP. Antifertility activity of some medicinal plants. Indian journal of experimental biology. 1968;6(4):252-3.
19. Lee K-HJJoNp. Current developments in the discovery and design of new drug candidates from plant natural product leads. 2004;67(2):273-83.
20. Telrandhe, U. B., Kosalge, S. B., Parihar, S., Sharma, D., & Hemalatha, S. (2022). Collection and cultivation of Swietenia macrophylla King. Sch Acad J Pharm, 1, 13-9.
21. Sharma HBJ. Flowering of Schizostachyum pergracile (Munro) RB Majumdar in Manipur. Indian Forester. 2014;140(6):633-5.
22. Moulishankar A, Ganesan P, Elumalai M, Lakshmanan KJJGPT. Significance of TLC and HPTLC in phytochemical screening of herbal drugs. 2020;13:30-45.
23. Adoga SO, Ekle DE, Kyenge BA, Aondo TO-O, Ikese COJOUAoC. Phytochemical screening, thin-layer chromatography and antimicrobial activity study of leaf extracts. 2019;30(2):88-94.
24. Turner R. Screening methods in pharmacology: Elsevier; 2013.
25. Chen P-J, Chiu C-H, Tseng J-K, Yang K-T, Chen Y-CJJoFF. Ameliorative effects of D-glucuronolactone on oxidative stress and inflammatory/fibrogenic responses in livers of thioacetamide-treated rats. 2015;14:154-62.
26. Oriakhi K, Uadia PO, Eze IGJCP. Hepatoprotective potentials of methanol extract of T. conophorum seeds of carbon tetrachloride induced liver damage in Wistar rats. 2018;4:1-12.
27. Abdel-Tawwab M, Eissa E-SH, Tawfik WA, Abd Elnabi HE, Saadony S, Bazina WK, et al. Dietary curcumin nanoparticles promoted the performance, antioxidant activity, and humoral immunity, and modulated the hepatic and intestinal histology of Nile tilapia fingerlings. 2022;48(3):585-601.
28. Carvalho ENd, Carvalho NASd, Ferreira LMJACB. Experimental model of induction of diabetes mellitus in rats. 2003;18:60-4.
29. Ramachandran S, Rajasekaran A, Adhirajan NJISRN. In vivo and in vitro antidiabetic activity of Terminalia paniculata bark: an evaluation of possible phytoconstituents and mechanisms for blood glucose control in diabetes. 2013;2013.
30. Prabhu S, Vijayakumar SJB, Nutrition P. Antidiabetic, hypolipidemic and histopathological analysis of Gymnema sylvestre (R. Br) leaves extract on streptozotocin induced diabetic rats. 2014;4(3):425-30.
2. Shahidi FJ. Nutraceuticals, functional foods and dietary supplements in health and disease. Journal of food and drug analysis. 2012;20(1):78.
3. El-Kaissi S, Sherbeeni SJ. Pharmacological management of type 2 diabetes mellitus: an update. Current diabetes reviews. 2011;7(6):392-405.
4. Hasbal G, Yilmaz-Ozden T, Can AJ. Antioxidant and antiacetylcholinesterase activities of Sorbus torminalis (L.) Crantz (wild service tree) fruits. Journal of food and drug analysis. 2015;23(1):57-62.
5. Asano NJ. Sugar-mimicking glycosidase inhibitors: bioactivity and application. Cellular and Molecular Life Sciences. 2009;66:1479-92.
6. Standl E, Schnell OJ. Alpha-glucosidase inhibitors 2012–cardiovascular considerations and trial evaluation. Diabetes and Vascular Disease Research. 2012;9(3):163-9.
7. Jung M, Park M, Lee HC, Kang Y-H, Kang ES, Kim SKJ. Antidiabetic agents from medicinal plants. Current medicinal chemistry. 2006;13(10):1203-18.
8. Jin H, Zhang Y-J, Jiang J-X, Zhu L-Y, Chen P, Li J, et al. Studies on the extraction of pumpkin components and their biological effects on blood glucose of diabetic mice. Journal of food and drug analysis. 2013;21(2):184-9.
9. Misbah H, Aziz AA, Aminudin NJ. Antidiabetic and antioxidant properties of Ficus deltoidea fruit extracts and fractions. BMC complementary and alternative medicine. 2013;13:1-12.
10. Niedowicz DM, Daleke DLJ. The role of oxidative stress in diabetic complications. Cell biochemistry and biophysics. 2005;43:289-330.
11. Spadiene A, Savickiene N, Ivanauskas L, Jakstas V, Skesters A, Silova A, et al. Antioxidant effects of Camellia sinensis L. extract in patients with type 2 diabetes. journal of food and drug analysis. 2014;22(4):505-11.
12. Niedowicz DM, Daleke DLJCb, biophysics. The role of oxidative stress in diabetic complications. Cell biochemistry and biophysics. 2005;43:289-330.
12. Parihar, S., Sharma, D. 2021. Cynodondactylon: A Review of Pharmacological Activities. Sch Acad J Pharm 11, 183-189.
13. Parihar, S., Sharma, D. 2021. Navagraha (nine planets) plants: the traditional uses and the therapeutic potential of nine sacred plants of india that symbolises nine planets. IJRAR 8 (4), 96-108.
14. Germano M, d’Angelo V, Biasini T, Sanogo R, De Pasquale R, Catania SJJoe. Evaluation of the antioxidant properties and bioavailability of free and bound phenolic acids from Trichilia emetica Vahl. 2006;105(3):368-73.
15. Chanda S, Dudhatra S, Kaneria MJF, function. Antioxidative and antibacterial effects of young shoots and fruit rind of nutraceutical plants belonging to the Fabaceae family. 2010;1(3):308-15.
16. Chopra RJCsidoIn, Calcutta. UN Dhar, Ltd SP. I. C. Chopra, KL Handa and LD Kapur. 1958.525.
17. Foster D, Cornella TJVA, D. VanNostrand Company Inc. Princeton, New Jersey, New York. Colorimetric Method of Analysis, Vol. 1961;162.
18. Bhaduri B, Ghose CR, Bose AN, Moza BK, Basu UP. Antifertility activity of some medicinal plants. Indian journal of experimental biology. 1968;6(4):252-3.
19. Lee K-HJJoNp. Current developments in the discovery and design of new drug candidates from plant natural product leads. 2004;67(2):273-83.
20. Telrandhe, U. B., Kosalge, S. B., Parihar, S., Sharma, D., & Hemalatha, S. (2022). Collection and cultivation of Swietenia macrophylla King. Sch Acad J Pharm, 1, 13-9.
21. Sharma HBJ. Flowering of Schizostachyum pergracile (Munro) RB Majumdar in Manipur. Indian Forester. 2014;140(6):633-5.
22. Moulishankar A, Ganesan P, Elumalai M, Lakshmanan KJJGPT. Significance of TLC and HPTLC in phytochemical screening of herbal drugs. 2020;13:30-45.
23. Adoga SO, Ekle DE, Kyenge BA, Aondo TO-O, Ikese COJOUAoC. Phytochemical screening, thin-layer chromatography and antimicrobial activity study of leaf extracts. 2019;30(2):88-94.
24. Turner R. Screening methods in pharmacology: Elsevier; 2013.
25. Chen P-J, Chiu C-H, Tseng J-K, Yang K-T, Chen Y-CJJoFF. Ameliorative effects of D-glucuronolactone on oxidative stress and inflammatory/fibrogenic responses in livers of thioacetamide-treated rats. 2015;14:154-62.
26. Oriakhi K, Uadia PO, Eze IGJCP. Hepatoprotective potentials of methanol extract of T. conophorum seeds of carbon tetrachloride induced liver damage in Wistar rats. 2018;4:1-12.
27. Abdel-Tawwab M, Eissa E-SH, Tawfik WA, Abd Elnabi HE, Saadony S, Bazina WK, et al. Dietary curcumin nanoparticles promoted the performance, antioxidant activity, and humoral immunity, and modulated the hepatic and intestinal histology of Nile tilapia fingerlings. 2022;48(3):585-601.
28. Carvalho ENd, Carvalho NASd, Ferreira LMJACB. Experimental model of induction of diabetes mellitus in rats. 2003;18:60-4.
29. Ramachandran S, Rajasekaran A, Adhirajan NJISRN. In vivo and in vitro antidiabetic activity of Terminalia paniculata bark: an evaluation of possible phytoconstituents and mechanisms for blood glucose control in diabetes. 2013;2013.
30. Prabhu S, Vijayakumar SJB, Nutrition P. Antidiabetic, hypolipidemic and histopathological analysis of Gymnema sylvestre (R. Br) leaves extract on streptozotocin induced diabetic rats. 2014;4(3):425-30.
Article Sidebar
Published
Aug 10, 2023
Article Details
How to Cite
Jitendra Chobdar, & Jai Singh Vaghela. (2023). ESTIMATE OF ETHANOLIC EXTRACT OF YOUNG SHOOTS OF BAMBUSA ARUNDINACEA FOR ANTIOXIDANT & ANTIDIABETIC ACTIVITIES. Journal of Population Therapeutics and Clinical Pharmacology, 30(16), 923–945. https://doi.org/10.53555/jptcp.v30i16.2558
Section
Articles
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Author Biographies
Jitendra Chobdar
Research Scholar, Department of Pharmacology, B.N. College of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan- 313001
Jai Singh Vaghela
Associate Professor, Department of Pharmacology, B.N. College of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan- 313001