Seed Mediated Synthesis of Silver Nanoparticles Using Phoenix Dactylifera & Its Anti-Inflammatory and Antioxidant Activity

Main Article Content

Manya Nautiyal
Suganya Panneer Selvam
Rajesh Kumar Shanmugam
Ramya Ramadoss
Sandhya Sundar
Pratibha Ramani


Nanoparticles, Antioxidant, Anti-Inflammatory, Activity


Introduction: Phoenix dactylifera commonly known as date palm belongs to the palm family, Arcaceae. Earlier studies demonstrate that constituents of dates act as potent antioxidant, antitumor and anti-inflammatory and provide a suitable alternative therapy in various disease.
Materials and methods: Dates seeds are grounded, mixed with distilled water, boiled & filtered. Silver nitrate is added to the solution & subjected to a magnetic stirrer. Tests done for anti-inflammatory activity are BSA and EA assay and tests done for antioxidant activity are DPPH and H2O2 assay.
Results: The anti-inflammatory & antioxidant activity of Phoenix dactylifera were roughly equal to the standard used in our study. Henceforth proving that they have high anti-inflammatory and antioxidant potential.
Conclusion: The study concludes that silver nanoparticles synthesized from the Phoenix dactylifera seeds exhibit good anti-inflammatory and antioxidant activity and hence can be used in the formulation of organic anti-inflammatory gels or as an adjuvant to NSAIDs.

Abstract 152 | PDF Downloads 82


1. Kumar, S., Kumar, P., & Pathak, C. S. (Eds.). (2021). Silver Micro-Nanoparticles: Properties, Synthesis, Characterization, and Applications. BoD–Books on Demand.
2. Salleh A, Naomi R, Utami ND, Mohammad AW, Mahmoudi E, Mustafa N, Fauzi MB. The Potential of Silver Nanoparticles for Antiviral and Antibacterial Applications: A Mechanism of Action. Nanomaterials. 2020; 10(8):1566.
3. Yaqoob, A.A., Umar, K. & Ibrahim, M.N.M. Silver nanoparticles: various methods of synthesis, size affecting factors and their potential applications–a review. Appl Nanosci 10, 1369–1378 (2020).
4. Ansari MA, Alzohairy MA. One-Pot Facile Green Synthesis of Silver Nanoparticles Using Seed Extract of Phoenix dactylifera and Their Bactericidal Potential against MRSA. Evid Based Complement Alternat Med. 2018 Jun 26;2018:1860280. doi: 10.1155/2018/1860280. PMID: 30046333; PMCID: PMC6038652.
5. Al-Alawi, R. A., Al-Mashiqri, J. H., Al-Nadabi, J. S., Al-Shihi, B. I., & Baqi, Y. (2017). Date palm tree (Phoenix dactylifera L.): natural products and therapeutic options. Frontiers in plant science, 8, 845.
6. Sennuga, A. T. (2011). Biological synthesis of metallic nanoparticles and their interactions with various biomedical targets (Doctoral dissertation, Rhodes University).
7. Al Matroudi A, Khadri H, Azam M, Rahmani AH, Al Khaleefah FK, Khareef R, Ansari MA, Allemailem KS. Antibacterial, Antibiofilm and Anticancer Activity of Biologically Synthesized Silver Nanoparticles Using Seed Extract of Nigella sativa. Processes. 2020; 8(4):388.
8. Kora et al- enhancement of anti bacterial activity of capped silver nanoparticles in combination with antibiotics on model gram positive and gram negative bacteria. Bioengi. Chem. Appl. 2013. 8,871097(Kora and Rastogi 2013)
9. Ashokkumar S, Ravi S, Velmurugan S. Green synthesis of silver nanoparticles from Gloriosa superba L. leaf extract and their catalytic activity [retracted in: Spectrochim
10. Chenthamara, D., Subramaniam, S., Ramakrishnan, S.G. et al. Therapeutic efficacy of nanoparticles and routes of administration. Biomater Res 23, 20 (2019).
11. Darvishi, S., Borghei, S. M., & Hashemizadeh, S. A. (2012). Structural, Optical and Electrical Properties of SilverNanoparticlesDeposited by Spin Coating Method. Journal of Nanostructures, 2(4), 501-504. doi: 10.7508/jns.2012.04.013
12. Khatami M, Alijani HQ, Nejad MS, Varma RS. Core@shell Nanoparticles: Greener Synthesis Using Natural Plant Products. Applied Sciences. 2018; 8(3):411.
13. Phongtongpasuk, S. , Poadang, S. , & Yongvanich, N. (2016). Environmental-friendly Method for Synthesis of Silver Nanoparticles from Dragon Fruit Peel Extract and their Antibacterial Activities. Energy Procedia, 89 . doi: 10.1016/j.egypro.2016.05.031
14. Mittal, A. K., Chisti, Y., & Banerjee, U. C. (2013). Synthesis of metallic nanoparticles using plant extracts. Biotechnology advances, 31(2), 346–356.
15. Parth Malik, Ravi Shankar, Vibhuti Malik, Nitin Sharma, Tapan Kumar Mukherjee, "Green Chemistry Based Benign Routes for Nanoparticle Synthesis", Journal of Nanoparticles, vol. 2014, Article ID 302429, 14 pages, 2014.
16. Sirry S M et al- biosynthesis of silver nano particles using the extracts of palm date seeds (Phoenix dactylifera) and its application in increasing the anti inflammatory effect of piroxicam drug. Adv. Nat. Sci. Nano tech. 2020. 11, 035017
17. Das, G., Patra, J. K., Debnath, T., Ansari, A., & Shin, H. S. (2019). Investigation of antioxidant, antibacterial, antidiabetic, and cytotoxicity potential of silver nanoparticles synthesized using the outer peel extract of Ananas comosus (L.). PloS one, 14(8), e0220950.
18. Salmen S.H Biosynthesis of Silver Nanoparticles from Date Seeds Extract and Evaluation of Antibacterial Activity Against Pathogenic Bacteria. Orient J Chem 2020;36(6)
19. Khushboo Shahbaz, Jawaad Ahmed Asif, Tang Liszen, Asma Abdullah Nurul, Mohammad Khursheed Alam, "Cytotoxic and Antioxidant Effects of Phoenix dactylifera L. (Ajwa Date Extract) on Oral Squamous Cell Carcinoma Cell Line", BioMed Research International, vol. 2022, Article ID 5792830, 16 pages, 2022.
20. Abdoh, Y. (2018). Chemical composition and antioxidant activity of date palm Fruit (Phoenix dactylifera) in Saudi Arabia(Doctoral dissertation, University of Nottingham).
21. Abdul-Hamid, N. A., Abas, F., Ismail, I. S., Tham, C. L., Maulidiani, M., Mediani, A., ... & Umashankar, S. (2019). 1H-NMR-based metabolomics to investigate the effects of Phoenix dactylifera seed extracts in LPS-IFN-γ-induced RAW 264.7 cells. Food Research International, 125, 108565.
22. Alajmi, R. A., Al-Megrin, W. A., Metwally, D., Al-Subaie, H., Altamrah, N., Barakat, A. M., ... & El-Khadragy, M. (2019). Anti-Toxoplasma activity of silver nanoparticles green synthesized with Phoenix dactylifera and Ziziphus spina-christi extracts which inhibits inflammation through liver regulation of cytokines in Balb/c mice. Bioscience Reports, 39(5).
23. Sahyon, H. A., & Al-Harbi, S. A. (2020). Antimicrobial, anticancer and antioxidant activities of nano-heart of Phoenix dactylifera tree extract loaded chitosan nanoparticles: In vitro and in vivo study. International Journal of Biological Macromolecules, 160, 1230-1241.
24. Taleb, H., Maddocks, S. E., Morris, R. K., & Kanekanian, A. D. (2016). Chemical characterisation and the anti-inflammatory, anti-angiogenic and antibacterial properties of date fruit (Phoenix dactylifera L.). Journal of ethnopharmacology, 194, 457-468.
25. Al-Shwyeh, H. A. (2019). Date palm (Phoenix dactylifera L.) fruit as potential antioxidant and antimicrobial agents. Journal of pharmacy & bioallied sciences, 11(1), 1.

Most read articles by the same author(s)

1 2 3 > >>