Comparison of Hemodynamic and APGAR Score Variables Due to Thiopental Sodium and Propofol as Induction Agent for Cesarean Section

Abstract

Introduction: A common surgical procedure performed to deliver a baby through incisions in the mother's abdomen and uterus is termed as Cesarean section. Two commonly used anesthetic agents for Cesarean section induction are Thiopental Sodium and Propofol. Hemodynamic variables such as heart rate, blood pressure, oxygen saturation, and APGAR score which assesses the newborn's condition at birth are affected by choice of anesthetic drug. This study aims to compare the effects of two anesthetic agents, Thiopental Sodium and Propofol, on hemodynamic variables and APGAR score in patients undergoing Cesarean section.
Methods: This is an interventional analytical study. Participants who met the inclusion criteria represented by Group C received Thiopental Sodium and Group D received Propofol. The study was conducted at Alexandria General Hospital in Babylon, Iraq, and collected data using non-invasive blood pressure monitors and pulse oximeters to assess variables such as (MAP), (SAP), (DAP), (HR). (SPO2) and neonatal condition (APGAR score). There is valuable information founded in the study about the effects of these inductive agents on maternal and neonatal outcomes in a relatively healthy population.
Results: In the study comparing different types of anesthesia during cesarean delivery, a total of 88 women were included, with 44 receiving Thiopental Sodium, and 44 receiving Propofol. There were significant differences in baseline Mean, systolic and diastolic arterial pressure, heart rate (HR base), and (APGAR) score between the two groups. The study found that Propofol initially had a higher mean values of (MAP, SAP, DAP) compared to Thiopental Sodium but it was lower at 5,10 minutes after intubation. The statistical analysis confirmed a significant association between the anesthesia agent and the (MAP, SAP, DAP) variable across different time points and anesthesia agents. (HR) and (APGAR) is higher in the propofol group than the Thiopental Sodium group in all time point.
Conclusion: The study concluded that Thiopental Sodium, and Propofol, during cesarean delivery, revealed significant differences in APGAR score, HR, and arterial blood pressure between the two groups. Propofol exhibited the highest baseline mean (MAP, SAP, DAP) in the first two points then it’s lesser than other group. In APGAR and HR variables, propofol exhibited the highest value in all time points. Healthcare professionals should carefully consider these factors when selecting anesthesia to optimize patient outcomes during cesarean delivery.