Role of injectable Platelet Rich Fibrin (iPRF) in Periodontal Therapy - A report on current evidence
Main Article Content
Keywords
Periodontal, platelet rich fibrin, biofilm, evidence, plaque
Abstract
The advent and emergence of the use of platelet concentrate in wound healing and regeneration has opened up an arena of possibilities to explore the potential of these biomimetic agents in periodontal regeneration. This review narrates the role of platelet concentrates in wound healing, regeneration and the literature evidence of use of iPRF in periodontal therapy.
References
1. Vitkov L, Singh J, Schauer C, Minnich B, Krunić J, Oberthaler H, et al. Breaking the Gingival Barrier in Periodontitis. Int J Mol Sci. 2023;24. doi:10.3390/ijms24054544
2. Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJL, Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014;93: 1045–1053.
3. Mootha A, Malaiappan S, Milstein DMJ, Karthikeyan G, Varghese SS, Jayakumar ND. Comparison of interleukin-21 levels and its correlation with clinical parameters among healthy individuals, chronic periodontitis, and aggressive periodontitis patients. Transl Res. 2021;7: 84–92.
4. Li J, Zhao G, Zhang HM, Zhu FF. Probiotic adjuvant treatment in combination with scaling and root planing in chronic periodontitis: a systematic review and meta-analysis. Benef Microbes. 2023; 1–14.
5. Nares S. Advances in Periodontal Surgery: A Clinical Guide to Techniques and Interdisciplinary Approaches. Springer; 2019.
6. Kavarthapu A, Malaiappan S. Comparative evaluation of demineralized bone matrix and type II collagen membrane versus eggshell powder as a graft material and membrane in rat model. Indian J Dent Res. 2019;30: 877–880.
7. Alghamdi H, Jansen J. Dental Implants and Bone Grafts: Materials and Biological Issues. Woodhead Publishing; 2019.
8. Sugiaman VK, Djuanda R, Pranata N, Naliani S, Demolsky WL, Jeffrey. Tissue Engineering with Stem Cell from Human Exfoliated Deciduous Teeth (SHED) and Collagen Matrix, Regulated by Growth Factor in Regenerating the Dental Pulp. Polymers . 2022;14. doi:10.3390/polym14183712
9. Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci U S A. 1974;71: 1207–1210.
10. Del Fabbro M, Karanxha L, Panda S, Bucchi C, Nadathur Doraiswamy J, Sankari M, et al.Autologous platelet concentrates for treating periodontal infrabony defects. Cochrane Database Syst Rev. 2018;11: CD011423.
11. Ravi S, Malaiappan S, Varghese S, Jayakumar ND, Prakasam G. Additive Effect of Plasma Rich in Growth Factors With Guided Tissue Regeneration in Treatment of Intrabony Defects in Patients With Chronic Periodontitis: A Split-Mouth Randomized Controlled Clinical Trial. J Periodontol. 2017;88: 839–845.
12. Panda S, Sankari M, Satpathy A, Jayakumar D, Mozzati M, Mortellaro C, et al. Adjunctive Effect of Autologus Platelet-Rich Fibrin to Barrier Membrane in the Treatment of Periodontal Intrabony Defects. J Craniofac Surg. 2016;27: 691–696.
13. Panda S, Doraiswamy J, Malaiappan S, Varghese SS, Del Fabbro M. Additive effect of autologous platelet concentrates in treatment of intrabony defects: a systematic review and meta-analysis. J Investig Clin Dent. 2016;7: 13–26.
14. Thamaraiselvan M, Elavarasu S, Thangakumaran S, Gadagi JS, Arthie T. Comparative clinical evaluation of coronally advanced flap with or without platelet rich fibrin membrane in the treatment of isolated gingival recession. J Indian Soc Periodontol. 2015;19: 66–71.
15. Pham TAV, Tran TTP. Antimicrobial effect against of advanced and injectable platelet-rich fibrin from patients with periodontal diseases versus periodontally healthy subjects. J Oral Biol Craniofac Res. 2023;13: 332–336.
16. Thanasrisuebwong P, Kiattavorncharoen S, Surarit R, Phruksaniyom C, Ruangsawasdi N. Red and Yellow Injectable Platelet-Rich Fibrin Demonstrated Differential Effects on Periodontal Ligament Stem Cell Proliferation, Migration, and Osteogenic Differentiation. Int J Mol Sci. 2020;21. doi:10.3390/ijms21145153
17. Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. European Journal of Trauma and Emergency Surgery. 2018. pp. 87–95. doi:10.1007/s00068-017-0767-9
18. Kızıltoprak M, Uslu MÖ. Comparison of the effects of injectable platelet-rich fibrin and autologous fibrin glue applications on palatal wound healing: a randomized controlled clinical trial. Clinical Oral Investigations. 2020. pp. 4549–4561. doi:10.1007/s00784-020-03320-6
19. Jasmine S, A. T, Janarthanan K, Krishnamoorthy R, Alshatwi AA. Antimicrobial
and antibiofilm potential of injectable platelet rich fibrin—a second-generation platelet concentrate—against biofilm producing oral staphylococcus isolates. Saudi Journal of Biological Sciences. 2020. pp. 41–46. doi:10.1016/j.sjbs.2019.04.012
20. Kyyak S, Blatt S, Schiegnitz E, Heimes D, Staedt H, Thiem DGE, et al. Activation of Human Osteoblasts via Different Bovine Bone Substitute Materials With and Without Injectable Platelet Rich Fibrin in vitro. Frontiers in Bioengineering and Biotechnology. 2021. doi:10.3389/fbioe.2021.599224
21. Aydinyurt HS, Sancak T, Taskin C, Basbugan Y, Akinci L. Effects of ınjectable platelet-rich fibrin in experimental periodontitis in rats. Odontology. 2021. pp. 422–432. doi:10.1007/s10266-020-00557-1
22. Miron RJ, Choukroun J. Platelet Rich Fibrin in Regenerative Dentistry: Biological Background and Clinical Indications. John Wiley & Sons; 2017.
23. Miron RJ, Chai J, Zhang P, Li Y, Wang Y, de Almeida Barros Mourão CF, et al. A novel method for harvesting concentrated platelet-rich fibrin (C-PRF) with a 10-fold increase in platelet and leukocyte yields. Clinical Oral Investigations. 2020. pp. 2819–2828. doi:10.1007/s00784-019-03147-w
24. Thanasrisuebwong P, Kiattavorncharoen S, Deeb GR, Bencharit S. Implant Site Preparation Application of Injectable Platelet-Rich Fibrin for Vertical and Horizontal Bone Regeneration: A Clinical Report. Journal of Oral Implantology. 2022. pp. 43–50. doi:10.1563/aaid-joi-d-20-00031
25. Dohle E, El Bagdadi K, Sader R, Choukroun J, James Kirkpatrick C, Ghanaati S. Platelet‐rich fibrin‐based matrices to improve angiogenesis in an in vitro co‐culture model for bone tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. 2018. pp. 598–610. doi:10.1002/term.2475
26. Zandim-Barcelos D. 04 / The influence of leukocyte and platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: a randomized clinical study. doi:10.26226/morressier.5ac3832d2afeeb00097a39f1
27. Gasparro R, Adamo D, Masucci M, Sammartino G, Mignogna MD. Use of injectable platelet-rich fibrin in the treatment of plasma cell mucositis of the oral cavity refractory to corticosteroid therapy: A case report. Dermatol Ther. 2019;32: e13062.
28. Bennardo F, Liborio F, Barone S, Antonelli A, Buffone C, Fortunato L, et al. Efficacy of platelet-rich fibrin compared with triamcinolone acetonide as injective therapy in the treatment of symptomatic oral lichen planus: a pilot study. Clinical Oral Investigations. 2021. pp. 3747–3755. doi:10.1007/s00784-020-03702-w
29. Saglam E, Ozsagir ZB, Unver T, Alinca SB, Toprak A, Tunali M. Efficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial. Journal of Applied Oral Science. 2021. doi:10.1590/1678-7757-2021-0180
30. Nageh M, Ibrahim LA, AbuNaeem FM, Salam E. Management of internal inflammatory root resorption using injectable platelet-rich fibrin revascularization technique: a clinical study with cone-beam computed tomography evaluation. Clinical Oral Investigations. 2022. pp. 1505–1516. doi:10.1007/s00784-021-04123-z
31. Rafiee A, Memarpour M, Najibi Y, Khalvati B, Kianpour S, Morowvat MH. Antimicrobial Efficacy of a Novel Antibiotic-Eluting Injectable Platelet-Rich Fibrin Scaffold against a Dual-Species Biofilm in an Infected Immature Root Canal Model. BioMed Research International. 2020. pp. 1–8. doi:10.1155/2020/6623830
32. Karde P, Sethi K, Mahale S, Khedkar S, Patil A, Joshi C. Comparative evaluation of platelet count and antimicrobial efficacy of injectable platelet-rich fibrin with other platelet concentrates: An in vitro study. Journal of Indian Society of Periodontology. 2017. p. 97. doi:10.4103/jisp.jisp_201_17
33. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Behavior of Gingival Fibroblasts on Titanium Implant Surfaces in Combination with either Injectable-PRF or PRP. Int J Mol Sci. 2017;18. doi:10.3390/ijms18020331
34. Vernon B. Injectable Biomaterials: Science and Applications. Elsevier; 2011.
35. Fujioka-Kobayashi M, Katagiri H, Kono M, Schaller B, Zhang Y, Sculean A, et al. Improved growth factor delivery and cellular activity using concentrated platelet-rich fibrin (C-PRF) when compared with traditional injectable (i-PRF) protocols. Clinical Oral Investigations. 2020. pp. 4373–4383. doi:10.1007/s00784-020-03303-7
36. Vuckovic M, Nikolic N, Milasin J, Djordjevic V, Milinkovic I, Asotic J, et al. The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis. Srpski arhiv za celokupno lekarstvo. 2020. pp. 280–285. doi:10.2298/sarh190925022v
37. Ucak Turer O, Ozcan M, Alkaya B, Surmeli S, Seydaoglu G, Haytac MC. Clinical evaluation of injectable platelet-rich fibrin with connective tissue graft for the treatment of deep gingival recession defects: A controlled randomized clinical trial. J Clin Periodontol. 2020;47: 72–80.
38. Ozsagir ZB, Saglam E, Yilmaz BS, Choukroun J, Tunali M. Injectable platelet‐rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial. Journal of Clinical Periodontology. 2020. pp. 489–499. doi:10.1111/jcpe.13247
39. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets. 2018. pp. 48–55. doi:10.1080/09537104.2017.1293807
40. Kyyak S, Blatt S, Pabst A, Thiem D, Al-Nawas B, Kämmerer PW. Combination of an allogenic and a xenogenic bone substitute material with injectable platelet-rich fibrin – A comparative in vitro study. Journal of Biomaterials Applications. 2020. pp. 83–96. doi:10.1177/0885328220914407
41. Shah R, Thomas R, Gowda TM, Baron TKA, Vemanaradhya GG, Bhagat S. In Vitro Evaluation of Osteoblast Response to the Effect of Injectable Platelet-rich Fibrin Coating on Titanium Disks. The Journal of Contemporary Dental Practice. 2021. pp. 107–110. doi:10.5005/jp-journals-10024-3039
42. Mu Z, Chen K, Yuan S, Li Y, Huang Y, Wang C, et al. Gelatin Nanoparticle‐Injectable Platelet‐Rich Fibrin Double Network Hydrogels with Local Adaptability and Bioactivity for Enhanced Osteogenesis. Advanced Healthcare Materials. 2020. p. 1901469. doi:10.1002/adhm.201901469
43. Lorenz J, Al-Maawi S, Sader R, Ghanaati S. Individualized Titanium Mesh Combined With Platelet-Rich Fibrin and Deproteinized Bovine Bone: A New Approach for Challenging Augmentation. Journal of Oral Implantology. 2018. pp. 345–351. doi:10.1563/aaid-joi-d-18-00049
44. Işık G, Günbay T, Uyanıkgil Y, Kısaog˘lu H, Yüce MÖ. Comparison of Autogenous Block Bone Graft and Screw Tent-Pole Techniques for Vertical Bone Augmentation in the Posterior Mandible: A Split-Mouth Randomized Controlled Study. Journal of Advanced Oral Research. 2021. pp. 159–169. doi:10.1177/2320206820976010
45. Wang M, Zhang X, Li Y, Mo A. Lateral Ridge Augmentation with Guided Bone Regeneration Using Particulate Bone Substitutes and Injectable Platelet-Rich Fibrin in a Digital Workflow: 6 Month Results of a Prospective Cohort Study Based on Cone-Beam Computed Tomography Data. Materials. 2021. p. 6430. doi:10.3390/ma14216430
46. Karcı İÇ, Baka ZM. Assessment of the effects of local platelet-rich fibrin injection and piezocision on orthodontic tooth movement during canine distalization. American Journal of Orthodontics and Dentofacial Orthopedics. 2021. pp. 29–40. doi:10.1016/j.ajodo.2020.03.029
47. Zeitounlouian TS, Zeno KG, Brad BA, Haddad RA. Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial. BMC Oral Health. 2021;21: 92.
48. Chai J, Jin R, Yuan G, Kanter V, Miron RJ, Zhang Y. Effect of Liquid Platelet-rich Fibrin and Platelet-rich Plasma on the Regenerative Potential of Dental Pulp Cells Cultured under Inflammatory Conditions: A Comparative Analysis. J Endod. 2019;45: 1000–1008.
49. Fujioka-Kobayashi M, Schaller B, De Almeida Barros Mourão CF, Zhang Y, Sculean A, Miron RJ. Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF). Platelets. 2021. pp. 74–81. doi:10.1080/09537104.2020.1717455
50. Kargarpour Z, Nasirzade J, Panahipour L, Miron RJ, Gruber R. Liquid PRF Reduces the Inflammatory Response and Osteoclastogenesis in Murine Macrophages. Front Immunol. 2021;12: 636427.
2. Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJL, Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014;93: 1045–1053.
3. Mootha A, Malaiappan S, Milstein DMJ, Karthikeyan G, Varghese SS, Jayakumar ND. Comparison of interleukin-21 levels and its correlation with clinical parameters among healthy individuals, chronic periodontitis, and aggressive periodontitis patients. Transl Res. 2021;7: 84–92.
4. Li J, Zhao G, Zhang HM, Zhu FF. Probiotic adjuvant treatment in combination with scaling and root planing in chronic periodontitis: a systematic review and meta-analysis. Benef Microbes. 2023; 1–14.
5. Nares S. Advances in Periodontal Surgery: A Clinical Guide to Techniques and Interdisciplinary Approaches. Springer; 2019.
6. Kavarthapu A, Malaiappan S. Comparative evaluation of demineralized bone matrix and type II collagen membrane versus eggshell powder as a graft material and membrane in rat model. Indian J Dent Res. 2019;30: 877–880.
7. Alghamdi H, Jansen J. Dental Implants and Bone Grafts: Materials and Biological Issues. Woodhead Publishing; 2019.
8. Sugiaman VK, Djuanda R, Pranata N, Naliani S, Demolsky WL, Jeffrey. Tissue Engineering with Stem Cell from Human Exfoliated Deciduous Teeth (SHED) and Collagen Matrix, Regulated by Growth Factor in Regenerating the Dental Pulp. Polymers . 2022;14. doi:10.3390/polym14183712
9. Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci U S A. 1974;71: 1207–1210.
10. Del Fabbro M, Karanxha L, Panda S, Bucchi C, Nadathur Doraiswamy J, Sankari M, et al.Autologous platelet concentrates for treating periodontal infrabony defects. Cochrane Database Syst Rev. 2018;11: CD011423.
11. Ravi S, Malaiappan S, Varghese S, Jayakumar ND, Prakasam G. Additive Effect of Plasma Rich in Growth Factors With Guided Tissue Regeneration in Treatment of Intrabony Defects in Patients With Chronic Periodontitis: A Split-Mouth Randomized Controlled Clinical Trial. J Periodontol. 2017;88: 839–845.
12. Panda S, Sankari M, Satpathy A, Jayakumar D, Mozzati M, Mortellaro C, et al. Adjunctive Effect of Autologus Platelet-Rich Fibrin to Barrier Membrane in the Treatment of Periodontal Intrabony Defects. J Craniofac Surg. 2016;27: 691–696.
13. Panda S, Doraiswamy J, Malaiappan S, Varghese SS, Del Fabbro M. Additive effect of autologous platelet concentrates in treatment of intrabony defects: a systematic review and meta-analysis. J Investig Clin Dent. 2016;7: 13–26.
14. Thamaraiselvan M, Elavarasu S, Thangakumaran S, Gadagi JS, Arthie T. Comparative clinical evaluation of coronally advanced flap with or without platelet rich fibrin membrane in the treatment of isolated gingival recession. J Indian Soc Periodontol. 2015;19: 66–71.
15. Pham TAV, Tran TTP. Antimicrobial effect against of advanced and injectable platelet-rich fibrin from patients with periodontal diseases versus periodontally healthy subjects. J Oral Biol Craniofac Res. 2023;13: 332–336.
16. Thanasrisuebwong P, Kiattavorncharoen S, Surarit R, Phruksaniyom C, Ruangsawasdi N. Red and Yellow Injectable Platelet-Rich Fibrin Demonstrated Differential Effects on Periodontal Ligament Stem Cell Proliferation, Migration, and Osteogenic Differentiation. Int J Mol Sci. 2020;21. doi:10.3390/ijms21145153
17. Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. European Journal of Trauma and Emergency Surgery. 2018. pp. 87–95. doi:10.1007/s00068-017-0767-9
18. Kızıltoprak M, Uslu MÖ. Comparison of the effects of injectable platelet-rich fibrin and autologous fibrin glue applications on palatal wound healing: a randomized controlled clinical trial. Clinical Oral Investigations. 2020. pp. 4549–4561. doi:10.1007/s00784-020-03320-6
19. Jasmine S, A. T, Janarthanan K, Krishnamoorthy R, Alshatwi AA. Antimicrobial
and antibiofilm potential of injectable platelet rich fibrin—a second-generation platelet concentrate—against biofilm producing oral staphylococcus isolates. Saudi Journal of Biological Sciences. 2020. pp. 41–46. doi:10.1016/j.sjbs.2019.04.012
20. Kyyak S, Blatt S, Schiegnitz E, Heimes D, Staedt H, Thiem DGE, et al. Activation of Human Osteoblasts via Different Bovine Bone Substitute Materials With and Without Injectable Platelet Rich Fibrin in vitro. Frontiers in Bioengineering and Biotechnology. 2021. doi:10.3389/fbioe.2021.599224
21. Aydinyurt HS, Sancak T, Taskin C, Basbugan Y, Akinci L. Effects of ınjectable platelet-rich fibrin in experimental periodontitis in rats. Odontology. 2021. pp. 422–432. doi:10.1007/s10266-020-00557-1
22. Miron RJ, Choukroun J. Platelet Rich Fibrin in Regenerative Dentistry: Biological Background and Clinical Indications. John Wiley & Sons; 2017.
23. Miron RJ, Chai J, Zhang P, Li Y, Wang Y, de Almeida Barros Mourão CF, et al. A novel method for harvesting concentrated platelet-rich fibrin (C-PRF) with a 10-fold increase in platelet and leukocyte yields. Clinical Oral Investigations. 2020. pp. 2819–2828. doi:10.1007/s00784-019-03147-w
24. Thanasrisuebwong P, Kiattavorncharoen S, Deeb GR, Bencharit S. Implant Site Preparation Application of Injectable Platelet-Rich Fibrin for Vertical and Horizontal Bone Regeneration: A Clinical Report. Journal of Oral Implantology. 2022. pp. 43–50. doi:10.1563/aaid-joi-d-20-00031
25. Dohle E, El Bagdadi K, Sader R, Choukroun J, James Kirkpatrick C, Ghanaati S. Platelet‐rich fibrin‐based matrices to improve angiogenesis in an in vitro co‐culture model for bone tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. 2018. pp. 598–610. doi:10.1002/term.2475
26. Zandim-Barcelos D. 04 / The influence of leukocyte and platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: a randomized clinical study. doi:10.26226/morressier.5ac3832d2afeeb00097a39f1
27. Gasparro R, Adamo D, Masucci M, Sammartino G, Mignogna MD. Use of injectable platelet-rich fibrin in the treatment of plasma cell mucositis of the oral cavity refractory to corticosteroid therapy: A case report. Dermatol Ther. 2019;32: e13062.
28. Bennardo F, Liborio F, Barone S, Antonelli A, Buffone C, Fortunato L, et al. Efficacy of platelet-rich fibrin compared with triamcinolone acetonide as injective therapy in the treatment of symptomatic oral lichen planus: a pilot study. Clinical Oral Investigations. 2021. pp. 3747–3755. doi:10.1007/s00784-020-03702-w
29. Saglam E, Ozsagir ZB, Unver T, Alinca SB, Toprak A, Tunali M. Efficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial. Journal of Applied Oral Science. 2021. doi:10.1590/1678-7757-2021-0180
30. Nageh M, Ibrahim LA, AbuNaeem FM, Salam E. Management of internal inflammatory root resorption using injectable platelet-rich fibrin revascularization technique: a clinical study with cone-beam computed tomography evaluation. Clinical Oral Investigations. 2022. pp. 1505–1516. doi:10.1007/s00784-021-04123-z
31. Rafiee A, Memarpour M, Najibi Y, Khalvati B, Kianpour S, Morowvat MH. Antimicrobial Efficacy of a Novel Antibiotic-Eluting Injectable Platelet-Rich Fibrin Scaffold against a Dual-Species Biofilm in an Infected Immature Root Canal Model. BioMed Research International. 2020. pp. 1–8. doi:10.1155/2020/6623830
32. Karde P, Sethi K, Mahale S, Khedkar S, Patil A, Joshi C. Comparative evaluation of platelet count and antimicrobial efficacy of injectable platelet-rich fibrin with other platelet concentrates: An in vitro study. Journal of Indian Society of Periodontology. 2017. p. 97. doi:10.4103/jisp.jisp_201_17
33. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Behavior of Gingival Fibroblasts on Titanium Implant Surfaces in Combination with either Injectable-PRF or PRP. Int J Mol Sci. 2017;18. doi:10.3390/ijms18020331
34. Vernon B. Injectable Biomaterials: Science and Applications. Elsevier; 2011.
35. Fujioka-Kobayashi M, Katagiri H, Kono M, Schaller B, Zhang Y, Sculean A, et al. Improved growth factor delivery and cellular activity using concentrated platelet-rich fibrin (C-PRF) when compared with traditional injectable (i-PRF) protocols. Clinical Oral Investigations. 2020. pp. 4373–4383. doi:10.1007/s00784-020-03303-7
36. Vuckovic M, Nikolic N, Milasin J, Djordjevic V, Milinkovic I, Asotic J, et al. The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis. Srpski arhiv za celokupno lekarstvo. 2020. pp. 280–285. doi:10.2298/sarh190925022v
37. Ucak Turer O, Ozcan M, Alkaya B, Surmeli S, Seydaoglu G, Haytac MC. Clinical evaluation of injectable platelet-rich fibrin with connective tissue graft for the treatment of deep gingival recession defects: A controlled randomized clinical trial. J Clin Periodontol. 2020;47: 72–80.
38. Ozsagir ZB, Saglam E, Yilmaz BS, Choukroun J, Tunali M. Injectable platelet‐rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial. Journal of Clinical Periodontology. 2020. pp. 489–499. doi:10.1111/jcpe.13247
39. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets. 2018. pp. 48–55. doi:10.1080/09537104.2017.1293807
40. Kyyak S, Blatt S, Pabst A, Thiem D, Al-Nawas B, Kämmerer PW. Combination of an allogenic and a xenogenic bone substitute material with injectable platelet-rich fibrin – A comparative in vitro study. Journal of Biomaterials Applications. 2020. pp. 83–96. doi:10.1177/0885328220914407
41. Shah R, Thomas R, Gowda TM, Baron TKA, Vemanaradhya GG, Bhagat S. In Vitro Evaluation of Osteoblast Response to the Effect of Injectable Platelet-rich Fibrin Coating on Titanium Disks. The Journal of Contemporary Dental Practice. 2021. pp. 107–110. doi:10.5005/jp-journals-10024-3039
42. Mu Z, Chen K, Yuan S, Li Y, Huang Y, Wang C, et al. Gelatin Nanoparticle‐Injectable Platelet‐Rich Fibrin Double Network Hydrogels with Local Adaptability and Bioactivity for Enhanced Osteogenesis. Advanced Healthcare Materials. 2020. p. 1901469. doi:10.1002/adhm.201901469
43. Lorenz J, Al-Maawi S, Sader R, Ghanaati S. Individualized Titanium Mesh Combined With Platelet-Rich Fibrin and Deproteinized Bovine Bone: A New Approach for Challenging Augmentation. Journal of Oral Implantology. 2018. pp. 345–351. doi:10.1563/aaid-joi-d-18-00049
44. Işık G, Günbay T, Uyanıkgil Y, Kısaog˘lu H, Yüce MÖ. Comparison of Autogenous Block Bone Graft and Screw Tent-Pole Techniques for Vertical Bone Augmentation in the Posterior Mandible: A Split-Mouth Randomized Controlled Study. Journal of Advanced Oral Research. 2021. pp. 159–169. doi:10.1177/2320206820976010
45. Wang M, Zhang X, Li Y, Mo A. Lateral Ridge Augmentation with Guided Bone Regeneration Using Particulate Bone Substitutes and Injectable Platelet-Rich Fibrin in a Digital Workflow: 6 Month Results of a Prospective Cohort Study Based on Cone-Beam Computed Tomography Data. Materials. 2021. p. 6430. doi:10.3390/ma14216430
46. Karcı İÇ, Baka ZM. Assessment of the effects of local platelet-rich fibrin injection and piezocision on orthodontic tooth movement during canine distalization. American Journal of Orthodontics and Dentofacial Orthopedics. 2021. pp. 29–40. doi:10.1016/j.ajodo.2020.03.029
47. Zeitounlouian TS, Zeno KG, Brad BA, Haddad RA. Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial. BMC Oral Health. 2021;21: 92.
48. Chai J, Jin R, Yuan G, Kanter V, Miron RJ, Zhang Y. Effect of Liquid Platelet-rich Fibrin and Platelet-rich Plasma on the Regenerative Potential of Dental Pulp Cells Cultured under Inflammatory Conditions: A Comparative Analysis. J Endod. 2019;45: 1000–1008.
49. Fujioka-Kobayashi M, Schaller B, De Almeida Barros Mourão CF, Zhang Y, Sculean A, Miron RJ. Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF). Platelets. 2021. pp. 74–81. doi:10.1080/09537104.2020.1717455
50. Kargarpour Z, Nasirzade J, Panahipour L, Miron RJ, Gruber R. Liquid PRF Reduces the Inflammatory Response and Osteoclastogenesis in Murine Macrophages. Front Immunol. 2021;12: 636427.
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Jun 1, 2023
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Thamaraiselvan Murugan, Jayakumar ND, & Dhanraj Ganapathy. (2023). Role of injectable Platelet Rich Fibrin (iPRF) in Periodontal Therapy - A report on current evidence. Journal of Population Therapeutics and Clinical Pharmacology, 30(12), 181–191. https://doi.org/10.47750/jptcp.2023.30.12.021
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