Serum Selenium Levels in Type 2 Diabetes Mellitus Patients
Main Article Content
Keywords
Selenium, oxidative stress, hyperglycemia and cardiovascular diseases
Abstract
Diabetes mellitus type 2 (T2DM) is a long-term metabolic disorder characterized by high blood glucose levels. T2DM is caused by insufficient insulin secretion by pancreatic β-cells and an inability of insulin-sensitive tissues to respond appropriately to insulin. In 2019, there are over 463 million people worldwide who have T2DM. Sixty T2DM patients and thirty healthy people served as controls. In terms of age and body mass index (BMI), these patients were comparable to a control group. This study determined demographics and serum selenium (Se). The findings of this study indicated a significant decrease in serum Se in T2DM patients compared to the healthy group. Many T2DM complications are caused by uncontrolled blood glucose and a decrease in antioxidant agents. Increased HbA1c is associated with an increased risk of serious microvascular and macrovascular complications. Low Se levels, on the other hand, increase reactive oxygen species (ROS), and Se deficiency is linked to a number of cardiovascular diseases, including myocardial infarction, cardiomyopathy, atherosclerosis, and coronary heart disease.
References
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20. Rains J.L., Jain S.K. Oxidative stress, insulin signaling, and diabetes. Free Radic. Biol. Med. 2011;50(5):567–575.
21. Rawshani A, Rawshani A, Franzen S, Sattar N, Eliasson B, Svensson AM, et al. Risk factors,
mortality, and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2018;379(7):633–644.
22. Rayman, M.P. Food-chain selenium and human health: Emphasis on intake. Br. J. Nutr. 2008, 100, 254–268 Rayman, M.P. Food-chain selenium and human .
23. Reinehr T, Karges B, Meissner T, et al.. Inflammatory Markers in obese adolescents with type 2 diabetes and their relationship to hepatokines and adipokines. J Pediatr 2016;173:131–5. 10.1016/j.jpeds.2016.02.055
24. Rodas Getachew Abera, Eyouel Shimeles Demesse and Wako Dedecha Boko Evaluation of glycemic control and related factors among outpatients with type 2 diabetes at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: a cross-sectional study Abera et al. BMC Endocrine Disorders (2022) 22:54.
25. Roman M., Jitaru P., Barbante C. Selenium biochemistry and its role for human health. Metallomics. 2014;6:25–54.
26. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R; IDF Diabetes Atlas Committee. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019 Nov;157:107843.
27. Shahid, M.; Niazi, N.K.; Khalid, S.; Murtaza, B.; Bibi, I.; Rashid, M.I. A critical review of selenium biogeochemical behavior in soil-plant system with an inference to human health. Environ. Pollut. 2018, 234, 915–934.
28. Shimada BK, Alfulaij N, Seale LA. The Impact of Selenium Deficiency on Cardiovascular Function. International Journal of Molecular Sciences. 2021; 22(19):10713.
29. Steinbrenner H. Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism. Free Radic. Biol. Med. 2013;65:1538–1547.
30. Traoré S, Guira O, Zoungrana L, et al. Factors associated with prolonged poor glycemic control in type 2 diabetes mellitus (T2DM) patients followed in the Department of Internal Medicine at the Yalgado Ouedraogo teaching hospital, Ouagadougou (Burkina Faso) Open J Intern Med. 2021;11:1–26.
31. Vrachnis N, Antonakopoulos N, Iliodromiti Z, et al.. Impact of maternal diabetes on epigenetic modifications leading to diseases in theoffspring. Exp Diabetes Res 2012;2012:1–6. 10.1155/2012/538474).
32. Wang N Tan HY, Li S, Xu Y, Guo W, Feng Y. Supplementation of micronutrient selenium in metabolic diseases: its role as an antioxidant. Oxid Med Cell Longev. 2017;2017:1.
33. Wang Y., Rijntjes E., Wu Q., et al. Selenium deficiency is linearly associated with hypoglycemia in healthy adults. Redox Biol. 2020;37:101709.
34. Wang, L.; Yin, J.; Guo, X. Serious selenium deficiency in the serum of patients with kashin-beck disease and the effect ofnano-selenium on
their chondrocytes. Biol. Trace Elem. Res. 2020, 194, 96–104.
35. Zhang H, Yan C, Yang Z, Zhang W, Niu Y, Li X, Qin L and Su Q. Alterations of serum trace elements in patients with type 2 diabetes. J Trace Elem Med Biol 2017; 40: 91-96.
36. Zixin Qiu, Tingting Geng, Zhenzhen Wan, Qi Lu, Jingyu Guo, Liegang Liu, An Pan, Gang Liu, Serum selenium concentrations and risk of all-cause and heart disease mortality among individuals with type 2 diabetes, The American Journal of Clinical Nutrition, Volume 115, Issue 1, January 2022, Pages 53–60.
2. Alexander Y, Osto E, Schmidt-Trucksäss A, Shechter M, Trifunovic D, Duncker DJ, et al.. Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis. Cardiovasc Res. (2021) 117:29–42.
3. Azzam MM, Ibrahim AA, Abd El-Ghany MI.Factors affecting glycemic control among Egyptian people with diabetes attending primary health care facilities in Mansoura District. Egypt J Crit Care. 2021;33:33.
4. Banik S, Ghosh A. The association of oxidative stress biomarkers with type 2 diabetes mellitus: A systematic review and meta-analysis. Health Sci Rep. 2021 Oct 1;4(4):e389.
5. Chen Y, Zhang XP, Yuan J, Cai B, Wang XL, Wu XL, Zhang YH, Zhang XY, Yin T, Zhu XH, Gu YJ, Cui SW, Lu ZQ, Li XY. Association of body mass index and age with incident diabetes in Chinese adults: a population-based cohort study. BMJ Open. 2018 Sep 28;8(9):e021768.
6. Eguchi, N.; Vaziri, N.D.; Dafoe, D.C.; Ichii, H. The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes. Int. J. Mol. Sci. 2021, 22, 1509.
7. Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, Ostolaza H, Martín C. Pathophysiology of Type 2 Diabetes Mellitus. Int J Mol Sci. 2020 Aug 30;21(17):6275.
8. Guo, L.; Xiao, J.; Liu, H.; Liu, H. Selenium nanoparticles alleviate hyperlipidemia and vascular injury in ApoE-deficient mice by regulating cholesterol metabolism and reducing oxidative stress. Metallomics 2020, 12, 204–217
9. Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW. Global trends in diabetes complications: a review of current evidence. Diabetologia. 2019;62(1):3–16.
10. Imai C, Li L, Hardie RA, Georgiou A. Adherence to guideline-recommended HbA1c testing frequency and better outcomes in patients with type 2 diabetes: a 5-year retrospective cohort study in Australian general practice. BMJ Qual Saf. 2021 Sep;30(9):706-714.
11. JasvinderSingh Bhatti , Abhishek Sehrawat , Jayapriya Mishra , InderpalSingh Sidhu , Umashanker Navik c, Naina Khullar , Shashank Kumar , Gurjit Kaur Bhatti , P. Hemachandra Reddy . Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives., 1 May 2022, Pages 114-134 .
12. Kim S.Y. It’s still not too late to make a change: Current status of glycemic control in Korea. J. Diabetes Metab. 2014;38:194–196. doi: 10.4093/dmj.2014.38.3.194.
13. Liu, X.; He, S.; Tan,W. Expression profile analysis of selenium-related genes in peripheral blood mononuclear cells of patients with Keshan disease. Biomed Res. Int. 2019, 2019, 4352905. Liu, X.; He, S.; Tan,W. Expression profile analysis of selenium-related genes in peripheral blood mononuclear cells of patients with Keshan disease. Biomed Res. Int. 2019, 2019, 4352905.
14. Moshfeghy, Z.; Bashiri, K.; Dabbaghmanesh, M.H.; Akbarzadeh, M.; Asadi, N.; Sayadi, M. The Predictive Value of Selenium in Diagnosis of Gestational Diabetes: A Nested Case-Control Study. Int. J. Gen. Med. 2020, 13, 53–60.
15. Mukai E, Fujimoto S, Inagaki N. Role of Reactive Oxygen Species in Glucose Metabolism Disorder in Diabetic Pancreatic β-Cells. Biomolecules. 2022; 12(9):122.
16. Nagalakshmi, V., Smruthi, V., Shama, Rathnakarashetty, G., Nallulwar, S.C., 2016. Cardiac Autonomic Neuropathy in Type II Diabetes Mellitus Patients and its Association with the Age of the Patient, Duration of Disease and Glycemic Control. Indian journal of physiology and pharmacology 60, 222-229.
17. Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay; on behalf of the American Diabetes Association, 6. Glycemic Targets: Standards of Care in Diabetes—2023. Diabetes Care 1 January 2023.
18. Nusca, Annunziata, Dario Tuccinardi, Claudio Proscia, Rosetta Melfi, Silvia ManfriniAntonio Nicolucci, Antonio Ceriello, Paolo Pozzilli, Gian Paolo Ussia, and Francesco Grigioni.. “Incremental Role of Glycaemic Variability over HbA1c in Identifying Type 2 Diabetic Patients with High Platelet Reactivity Undergoing Percutaneous Coronary Intervention.” Cardiovascular Diabetology 2019.18 (1): 147.
19. Ohishi, M. Hypertension with diabetes mellitus: Physiology and pathology. Hypertens. Res. 2018, 41, 389–393.
20. Rains J.L., Jain S.K. Oxidative stress, insulin signaling, and diabetes. Free Radic. Biol. Med. 2011;50(5):567–575.
21. Rawshani A, Rawshani A, Franzen S, Sattar N, Eliasson B, Svensson AM, et al. Risk factors,
mortality, and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2018;379(7):633–644.
22. Rayman, M.P. Food-chain selenium and human health: Emphasis on intake. Br. J. Nutr. 2008, 100, 254–268 Rayman, M.P. Food-chain selenium and human .
23. Reinehr T, Karges B, Meissner T, et al.. Inflammatory Markers in obese adolescents with type 2 diabetes and their relationship to hepatokines and adipokines. J Pediatr 2016;173:131–5. 10.1016/j.jpeds.2016.02.055
24. Rodas Getachew Abera, Eyouel Shimeles Demesse and Wako Dedecha Boko Evaluation of glycemic control and related factors among outpatients with type 2 diabetes at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: a cross-sectional study Abera et al. BMC Endocrine Disorders (2022) 22:54.
25. Roman M., Jitaru P., Barbante C. Selenium biochemistry and its role for human health. Metallomics. 2014;6:25–54.
26. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R; IDF Diabetes Atlas Committee. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019 Nov;157:107843.
27. Shahid, M.; Niazi, N.K.; Khalid, S.; Murtaza, B.; Bibi, I.; Rashid, M.I. A critical review of selenium biogeochemical behavior in soil-plant system with an inference to human health. Environ. Pollut. 2018, 234, 915–934.
28. Shimada BK, Alfulaij N, Seale LA. The Impact of Selenium Deficiency on Cardiovascular Function. International Journal of Molecular Sciences. 2021; 22(19):10713.
29. Steinbrenner H. Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism. Free Radic. Biol. Med. 2013;65:1538–1547.
30. Traoré S, Guira O, Zoungrana L, et al. Factors associated with prolonged poor glycemic control in type 2 diabetes mellitus (T2DM) patients followed in the Department of Internal Medicine at the Yalgado Ouedraogo teaching hospital, Ouagadougou (Burkina Faso) Open J Intern Med. 2021;11:1–26.
31. Vrachnis N, Antonakopoulos N, Iliodromiti Z, et al.. Impact of maternal diabetes on epigenetic modifications leading to diseases in theoffspring. Exp Diabetes Res 2012;2012:1–6. 10.1155/2012/538474).
32. Wang N Tan HY, Li S, Xu Y, Guo W, Feng Y. Supplementation of micronutrient selenium in metabolic diseases: its role as an antioxidant. Oxid Med Cell Longev. 2017;2017:1.
33. Wang Y., Rijntjes E., Wu Q., et al. Selenium deficiency is linearly associated with hypoglycemia in healthy adults. Redox Biol. 2020;37:101709.
34. Wang, L.; Yin, J.; Guo, X. Serious selenium deficiency in the serum of patients with kashin-beck disease and the effect ofnano-selenium on
their chondrocytes. Biol. Trace Elem. Res. 2020, 194, 96–104.
35. Zhang H, Yan C, Yang Z, Zhang W, Niu Y, Li X, Qin L and Su Q. Alterations of serum trace elements in patients with type 2 diabetes. J Trace Elem Med Biol 2017; 40: 91-96.
36. Zixin Qiu, Tingting Geng, Zhenzhen Wan, Qi Lu, Jingyu Guo, Liegang Liu, An Pan, Gang Liu, Serum selenium concentrations and risk of all-cause and heart disease mortality among individuals with type 2 diabetes, The American Journal of Clinical Nutrition, Volume 115, Issue 1, January 2022, Pages 53–60.
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Published
May 6, 2023
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How to Cite
Baneen Sami Tarif, & Zainab Hussein AL-Hellawi. (2023). Serum Selenium Levels in Type 2 Diabetes Mellitus Patients. Journal of Population Therapeutics and Clinical Pharmacology, 30(9), 376–382. https://doi.org/10.47750/jptcp.2023.30.09.038
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All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.