The Concept of Cancer Translational Research - A Review

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S. Ramachandran
Ramam Sripada
Lakshmi Himaja Bandaru
P. Himasree


Chemotherapy, Oncology, Palliative care, Translational Research


The translational research is a multidisciplinary research model which includes the process of discovering the concepts of research by using basic science and applying that knowledge with in the clinical praxis. This model appears to be well constructed and highly systematic and it bridges the concept of basic research and the clinical practice. This research paradigm is one of the basis for developing translational medicine which leads to progression of evidence based medicine to solve the public health issues. In this review, the concept of translational research along with various stages, cancer therapeutics & prevention, the main reasons for inadequate therapeutics along with contemporary and future perspectives were discussed. The terminal goal of translational research is to identify the therapeutic guidelines and regimes which are highly effective with low toxicity. The evolution of biotechnology lead to the development of indisputable chances for ameliorating the ability to diagnose, treat and prevent the neoplasms. Preclinical investigations are undergoing for latest developments and advancements in the molecular biology or molecular targeted therapies which lead to the increased identification of the latest agents for treatment. For the expected quality of oncological practice large variety of molecular tumor characteristics and their supporting models will be helpful for allowing continuous reassessment of human malignancies at molecular level. In conclusion, translational research can be used to improve the public health outcomes and can develop the therapeutic and preventive strategies regarding various diseases or disorders and can provide cost benefit health care analysis. Thus, consistent efforts in translational research stimulate the logical and reasonable inventions in the field of multidisciplinary cancer research in future.

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