GREEN NANOTECHNOLOGY IN PHARMACEUTICAL FORMULATIONS: DEVELOPMENT, CHARACTERIZATION, AND THERAPEUTIC POTENTIAL OF BIOGENIC NANOPARTICLES
Main Article Content
Keywords
Green nanotechnology, biogenic nanoparticles, drug delivery, antimicrobial activity, anticancer activity, chitosan nanoparticles
Abstract
Green nanotechnology presents a sustainable and environmental friendly method of producing nanoparticles that have possible pharmaceutical uses. It was the purpose of this study to design, describe, and assess the therapeutic value of biogenic nanoparticles produced with the help of plant extracts, microbial metabolites, and natural polymers. UV-Visible spectroscopy, FTIR, XRD, TEM /SEM and DLS were used to characterize the nanoparticles, i.e., silver (AgNPs), gold (AuNPs), zinc oxide (ZnO NPs), and chitosan-based polymeric nanoparticles. Findings were validated by the fact that the nanoparticles were mainly of spherical and nanosized and stable with negative or positive zeta potential making them colloidally stable. The efficiency of drug encapsulation was 72-88 percent and drug release was proved to be controlled and sustained especially with polymeric nanoparticles. Biological tests showed that it had a high antimicrobial activity against Gram-positive and Gram-negative microbes, an anticancer effect was high and low toxicity to normal cells, and it had a high antinflammatory effect. The results show that biogenic nanoparticles produced in green are multifunctional, biocompatible and have therapeutic and drug delivery uses. This paper draws attention to the originality and sustainability of the green synthesis methods which will serve as a basis of further research on scalable manufacturing, in vivo research and clinical applications.
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Mian inaam zeb
Abdul wali khan university mardan
Shahid Anwar
Production pharmacist, Delta Phamail : rma (Pvt) Ltd.
Kiran akbar
Lecturer, vertex college of pharmacy.
Sidra younas
Abdul wali khan university mardan
Asif Mahmood
Wellborne Pharmachem and Biologicals
Shah zaib khan
University of Malakand.
